18F-NaF and 18F-FDG PET/CT in gorham-stout disease
Clinical Nuclear Medicine, 41(11), 884–885
Abstract
Gorham-Stout disease (GSD) is an extremely rare skeletal disorder of unknown etiology characterized by benign proliferation of vascular or lymphatic channels, leading to progressive bone resorption. We report on a patient diagnosed with GSD affecting the right scapula and the right ribs, who underwent PET/CT scans using F-FDG and F-NaF. The remnant upper portion of the affected scapula did not show F-FDG uptake but demonstrated markedly increased F-NaF activity. Furthermore, intense F-NaF activity was seen on the right posterior ribs, which were actively being resorbed, suggesting the potential application of F-NaF-PET/CT imaging in GSD diagnosis and follow-up.
Abstract sourceThis 2016 case report compares 18F-NaF and 18F-FDG PET/CT findings in one patient with Gorham-Stout disease. The authors describe increased 18F-NaF activity in areas of bone resorption and suggest its potential use in disease assessment.
Summary
In this case report, the authors describe a patient with Gorham-Stout disease affecting the right scapula and ribs who underwent PET/CT using 18F-FDG and 18F-NaF. The residual upper portion of the affected scapula showed no 18F-FDG uptake but markedly increased 18F-NaF activity; intense 18F-NaF activity was also reported in actively resorbing right posterior ribs. The authors suggest that 18F-NaF PET/CT may have potential for disease diagnosis and follow-up. The report concerns a single patient and does not establish diagnostic performance or clinical utility.
- Authors: Georgios Z. Papadakis, Corina Millo, Ulas Bagci, Jenny Blau, and Michael T. Collins.
- Clinical Nuclear Medicine, 41(11), 884–885 (2016).
- DOI: 10.1097/RLU.0000000000001369.
Cite this work
Georgios Z. Papadakis; Corina Millo; Ulas Bagci; Jenny Blau; Michael T. Collins (2016). 18F-NaF and 18F-FDG PET/CT in gorham-stout disease. Clinical Nuclear Medicine, 41(11), 884–885 https://doi.org/10.1097/RLU.0000000000001369
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