18F-NaF PET/CT in extensive melorheostosis of the axial and appendicular skeleton with soft-tissue involvement
Clinical Nuclear Medicine. 2017 Jul;42(7):537-539.
Abstract
Melorheostosis is a rare, nonhereditary, benign, sclerotic bone dysplasia with no sex predilection, typically occurring in late childhood or early adulthood, which can lead to substantial functional morbidity, depending on the sites of involvement. We report on a patient with extensive melorheostosis in the axial and appendicular skeleton, as well as in the soft tissues, who was evaluated with whole-body F-NaF PET/CT scan. All melorheostotic lesions of the skeleton and of the ossified soft-tissue masses demonstrated intensely increased F-NaF activity, suggesting the application of this modality in assessing and monitoring the disease activity.
Abstract sourceThis 2017 case report describes whole-body 18F-NaF PET/CT findings in one patient with extensive melorheostosis involving the axial and appendicular skeleton and ossified soft tissues. The authors report increased tracer activity at the identified lesions and suggest potential use in assessing and monitoring disease activity.
Summary
The authors report a whole-body 18F-NaF PET/CT scan in one patient with extensive melorheostosis affecting the axial and appendicular skeleton, with ossified soft-tissue masses. They describe increased 18F-NaF activity in the skeletal lesions and ossified soft-tissue masses, and suggest that the imaging modality may help assess and monitor disease activity. This is a case report; its findings do not establish diagnostic performance or validate prospective monitoring in a broader patient population. Read the full text.
- Georgios Z. Papadakis
- Smita Jha
- Timothy Bhattacharyya
- Corina Millo
- Tsang-Wei Tu
- Ulas Bagci
- Kostas Marias
- Apostolos H. Karantanas
- Nicholas J. Patronas
Cite this work
Georgios Z. Papadakis; Smita Jha; Timothy Bhattacharyya; Corina Millo; Tsang-Wei Tu; Ulas Bagci; Kostas Marias; Apostolos H. Karantanas; Nicholas J. Patronas (2017). 18F-NaF PET/CT in extensive melorheostosis of the axial and appendicular skeleton with soft-tissue involvement. Clinical Nuclear Medicine. 2017 Jul;42(7):537-539. https://doi.org/10.1097/RLU.0000000000001647
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