Avascular necrosis of the hips with increased activity on 68ga-dotatate PET/CT
Clinical Nuclear Medicine, 42(3), 214–215
Abstract
Prolonged exposure to cortisol is one of the major causes of avascular bone necrosis (AVN). We report on a case of a woman with Cushing syndrome attributed to ectopic adrenocorticotropic hormone-secreting tumor who was evaluated with whole-body PET/CT study using Ga-DOTATATE. The scan showed increased activity by both femoral heads, corresponding to the margins of bilateral AVN seen on MRI. The presented data suggests AVN-induced reactive inflammatory alterations adjacent to the necrotic segment of the bone, which can be effectively targeted using radiolabeled somatostatin (SST) analogs.
Abstract sourceThis 2017 case report describes increased 68Ga-DOTATATE activity at the margins of bilateral hip avascular necrosis in a patient with Cushing syndrome. The authors suggest the uptake may reflect reactive inflammatory changes; the observation is from a single case.
Summary
The report describes a woman with Cushing syndrome attributed to an ectopic adrenocorticotropic hormone-secreting tumor. On whole-body PET/CT using 68Ga-DOTATATE, increased activity was seen at both femoral heads, corresponding to the margins of bilateral avascular necrosis identified on MRI. The authors suggest that the uptake may indicate reactive inflammatory alterations adjacent to necrotic bone. This is a single-patient case report, not a clinical validation study. Read the article on PubMed or view the full text in PubMed Central.
Cite this work
Georgios Z. Papadakis, Corina Millo, Apostolos H. Karantanas, Ulas Bagci, Nicholas J. Patronas (2017). Avascular necrosis of the hips with increased activity on 68ga-dotatate PET/CT. Clinical Nuclear Medicine, 42(3), 214–215 https://doi.org/10.1097/RLU.0000000000001513
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