Breast fibroadenoma with increased activity on 68ga-dotatate PET/CT
Clinical Nuclear Medicine, 42(2), 145–146
Abstract
Fibroadenoma is the most common benign breast tumor in women of reproductive age, carrying little to no risk of breast cancer development. We report on a case of a woman with history of neuroendocrine tumor who on follow-up imaging tests underwent whole-body PET/CT study using Ga DOTATATE. The scan showed increased focal activity in the right breast, which was biopsied revealing a fibroadenoma. The presented data suggests cell surface overexpression of somatostatin receptors by this benign breast tumor. Moreover, this finding emphasizes the need for cautious interpretation of Ga DOTATATE-avid breast lesions that could mimic malignancy in neuroendocrine tumor patients.
Abstract sourceThis 2017 case report describes a biopsy-confirmed breast fibroadenoma with increased activity on 68Ga-DOTATATE PET/CT. The finding illustrates why focal uptake should be interpreted in clinical context and does not, by itself, establish metastatic disease.
Summary
The authors report a patient with a history of neuroendocrine tumor whose 68Ga-DOTATATE PET/CT showed focal activity in the right breast. Excisional biopsy identified the lesion as a fibroadenoma. The report notes that benign breast lesions can show increased tracer activity and may resemble metastases on imaging; it emphasizes interpreting such findings alongside the patient's history and other imaging.
Cite this work
Georgios Z. Papadakis, Corina Millo, Samira M. Sadowski, Apostolos H. Karantanas, Ulas Bagci, Nicholas J. Patronas (2017). Breast fibroadenoma with increased activity on 68ga-dotatate PET/CT. Clinical Nuclear Medicine, 42(2), 145–146 https://doi.org/10.1097/RLU.0000000000001463
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