Epididymal cystadenomas in von hippel-lindau disease showing increased activity on 68ga dotatate PET/CT
Clinical Nuclear Medicine, 41(10), 781–782
Abstract
von Hippel-Lindau (VHL) disease is a familial cancer syndrome characterized by the development of a variety of malignant and benign tumors, including epididymal cystadenomas. We report a case of a VHL patient with bilateral epididymal cystadenomas who was evaluated with Ga DOTATATE PET/CT, showing intensely increased activity (SUVmax, 21.6) associated with the epididymal cystadenomas, indicating cell-surface overexpression of somatostatin receptors. The presented case supports the usefulness of somatostatin receptor imaging using Ga DOTA-conjugated peptides for detection and follow-up of VHL manifestations, as well as surveillance of asymptomatic gene carriers.
Abstract sourceThis 2016 case report describes increased 68Ga-DOTATATE uptake in bilateral epididymal cystadenomas in a patient with von Hippel-Lindau disease. The authors discuss the potential relevance of somatostatin-receptor imaging, while the evidence is limited to a single reported case.
Summary
The authors report a patient with von Hippel-Lindau (VHL) disease whose bilateral epididymal cystadenomas showed increased activity on 68Ga-DOTATATE PET/CT, with a reported SUVmax of 21.6. They interpret the finding as indicating cell-surface overexpression of somatostatin receptors and discuss possible relevance to imaging VHL manifestations. This is a case report; it does not establish diagnostic performance or clinical benefit in a broader patient population.
Cite this work
Georgios Z. Papadakis, Corina Millo, Samira M. Sadowski, Ulas Bagci, Nicholas J. Patronas (2016). Epididymal cystadenomas in von hippel-lindau disease showing increased activity on 68ga dotatate PET/CT. Clinical Nuclear Medicine, 41(10), 781–782 https://doi.org/10.1097/RLU.0000000000001314
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