Fibrous dysplasia mimicking malignancy on 68ga-dotatate PET/CT
Clinical Nuclear Medicine, 42(3), 209–210
Abstract
Fibrous dysplasia of the bone is a developmental benign skeletal disorder characterized by replacement of normal bone and normal bone marrow with abnormal fibro-osseous tissue. We report on a case of a biopsy-proven fibrous dysplasia lesion in the left temporal bone, with intensely increased activity (SUVmax, 56.7) on Ga-DOTATATE PET/CT. The presented data indicate cell surface overexpression of somatostatin receptors by fibrous dysplastic cells and highlight the need of cautious management of Ga-DOTATATE-avid bone lesions, which could mimic malignancy especially in patients with history of neuroendocrine tumors.
Abstract sourceThis 2017 case report describes biopsy-proven fibrous dysplasia with intense uptake on 68Ga-DOTATATE PET/CT, illustrating how a benign bone lesion can resemble malignancy on imaging.
Summary
The authors report a biopsy-proven fibrous dysplasia lesion in the left temporal bone that showed intense activity on 68Ga-DOTATATE PET/CT. The case highlights that an avid bone lesion on this imaging study may be benign and can mimic malignancy, including in patients being evaluated for neuroendocrine tumors. As a single case report, it does not establish diagnostic performance or clinical readiness.
Cite this work
Georgios Z. Papadakis, Corina Millo, Samira M. Sadowski, Apostolos H. Karantanas, Ulas Bagci, Nicholas J. Patronas (2017). Fibrous dysplasia mimicking malignancy on 68ga-dotatate PET/CT. Clinical Nuclear Medicine, 42(3), 209–210 https://doi.org/10.1097/RLU.0000000000001527
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