The use of radiolabelled 18-f-2-deoxy-2-fluro-glucose (18-FDG) in combined positron emission tomography-computed tomography (PET-CT) to evaluate infection: lessons learned from a case series of 23 patients with chronic granulomatous disease (CGD)
Journal of Allergy and Clinical Immunology, 135(2), AB98; abstract 316 presented at the American Academy of Allergy, Asthma & Immunology Annual Meeting
Abstract
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This conference abstract reports observations from 18F-FDG PET-CT imaging in 23 patients with chronic granulomatous disease. The case series describes uptake patterns in infection, residual lung lesions, lymphadenopathy and musculoskeletal findings, and notes the need for clinical correlation.
Summary
This case series describes 18F-FDG PET-CT imaging in 23 patients with chronic granulomatous disease (CGD), a disorder associated with susceptibility to serious infections. The authors report observations about tracer uptake at known infection sites, in stable residual pulmonary lesions, in lymphadenopathy, and in musculoskeletal findings. They conclude that further studies are needed to determine whether biopsy targeted to areas of highest uptake improves diagnostic yield. These observations do not establish prospective diagnostic performance or clinical readiness.
Cite this work
Amanda K. Rudman Spergel; Clara C. Chen; Cheryl Ann Beegle; Patricia Littel; Mary Garofalo; Sandra Anaya-O’Brien; Martha Marquesen; Ulas Bagci; Daniel J. Mollura; John I. Gallin; Harry L. Malech (2015). The use of radiolabelled 18-f-2-deoxy-2-fluro-glucose (18-FDG) in combined positron emission tomography-computed tomography (PET-CT) to evaluate infection: lessons learned from a case series of 23 patients with chronic granulomatous disease (CGD). Journal of Allergy and Clinical Immunology, 135(2), AB98; abstract 316 presented at the American Academy of Allergy, Asthma & Immunology Annual Meeting https://doi.org/10.1016/j.jaci.2014.12.1254
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